Cardiometabolic Factors and Breast Cancer: A Case-Control Study in Women
Niki Mourouti1, Christos Papavagelis1, Meropi D. Kontogianni1, Petrini Plytzanopoulou2, Tonia Vassilakou2, Nikolaos Malamos3, Athena Linos4, Demosthenes B. Panagiotakos1, *
Identifiers and Pagination:Year: 2013
First Page: 49
Last Page: 49
Publisher Id: TOHYPERJ-5-49
Article History:Received Date: 09/10/2013
Revision Received Date: 11/10/2013
Acceptance Date: 11/10/2013
Electronic publication date: 15/11/2013
Collection year: 2013
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Previous studies have suggested that individual cardiometabolic factors may be associated with an increased risk of breast cancer.
To evaluate the association between individual cardiometabolic factors with breast cancer development.
A case – control study. Two-hundred-and-fifty consecutive, newly diagnosed breast cancer female patients (56±12 years) and 250, one-to-one age-matched with the patients, healthy volunteers (controls), were studied. A standardized, validated questionnaire assessing various socio-demographic, clinical, lifestyle and dietary characteristics, was applied through face-to-face interviews. Adherence to the Mediterranean diet was evaluated using the 11-components MedDietScore (theoretical range 0-55). A detailed medical history regarding the common co-morbidities (i.e., diabetes, hypertension, hypercholesterolemia) and their treatment was also recorded, while women were also categorized using the Body Mass Index (BMI) as an indicator of obesity.
Obesity (i.e., BMI>30 kg/m2) was positively associated with the likelihood of having breast cancer.
With the exception of obesity, none of the other tested cardiometabolic risk factors seemed to be a predisposing factor for breast cancer development.