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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Volume 21, 18 Issues, 2021
ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)
This journal supports open access

Aims & Scope

Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.

Each issue contains a series of timely in-depth/mini reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication.

Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.

Anti-Cancer Agents in Medicinal Chemistry, Volume 21 (2021) - Number 13


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Inhibition of Growth of Esophageal Cancer by Alantolactone via Wnt/β- Catenin Signaling


Zijie Wang, Qing Hu, Huan Chen, Lei Shi, Min He, Hui Liu, Ting Li, Muhan Lü, Mingming Deng* and Gang Luo*


DOI: 10.2174/1871520621666210112124546
View Abstract View on PubMed



The LncRNA MIR155HG is Upregulated by SP1 in Melanoma Cells and Drives Melanoma Progression via Modulating the MiR-485-3p/PSIP1 Axis


Jia Huo, Yuan Wang, Yanfei Zhang, Wei Wang, Peiwen Yang, Wenwei Zhao, Miaomiao Zhang, Lu Cui and Dingwei Zhang*


DOI: 10.2174/1871520621666210322092906
View Abstract


A Review of Anti-Cancer and Related Properties of Lichen-Extracts and Metabolites


Ankita H. Tripathi, Nidhi Negi, Rekha Gahtori, Amrita Kumari, Penny Joshi, Lalit M. Tewari, Yogesh Joshi, Rajesh Bajpai, Dalip K. Upreti and Santosh K. Upadhyay*


DOI: 10.2174/1871520621666210322094647
View Abstract


Traditionally Used Natural Products in Preventing Ionizing Radiation-Induced Dermatitis: First Review on the Clinical Studies


Faizan Kalekhan, Avinash K. Kudva, Shamprasad V. Raghu, Suresh Rao, Sanath K. Hegde, Paul Simon and Manjeshwar S. Baliga*


DOI: 10.2174/1871520621666210405093236
View Abstract View on PubMed


Diagnostic and Therapeutic Applications of Exosome Nanovesicles in Lung Cancer: State-of-The-Art


Rezvan Mohammadi, Seyede A. Hosseini, Somaye Noruzi, Ailin Ebrahimzadeh and Amirhossein Sahebkar*


DOI: 10.2174/1871520621666210301085318
View Abstract View on PubMed


Zebrafish Avatar to Develop Precision Breast Cancer Therapies


Debora Corsinovi, Alice Usai, Miriam De Sarlo, Martina Giannaccini and Michela Ori*


DOI: 10.2174/1871520621666210402111634
View Abstract View on PubMed



Radioprotective Role of Natural Polyphenols: From Sources to Mechanisms


Muhammad Adnan, Azhar Rasul, Muhammad A. Shah, Ghulam Hussain, Muhammad Asrar, Ammara Riaza, Iqra Sarfraza, Arif Hussaina, Khatereh Khorsandid, Ngit S. Laie and Syed M. Hussaina*


DOI: 10.2174/1871520621666210419095829
View Abstract View on PubMed


Synthesis and Biological Evaluation of New 1,2,3-Triazole Derivatives of the Chrysin Flavonoid as Anticancer Agents


Venkatagiri Noole, Thotla Krishna, Sudhakar Godeshala, Seyedehmelika Meraji, Kaushal Rege, Chepyala K. Reddy* and Bhavani Kedika*


DOI: 10.2174/1871520621666210315090527
View Abstract View on PubMed


Abstracts Ahead of Print


Nitric Oxide Synthase Potentiates the Resistance of Cancer Cell Lines to Anticancer Chemotherapeutics


Ibrahim Barnawi, Yousef Hawsawi, Philip Dash, Atif Abdulwahab A. Oyouni, Syed Khalid Mustafa, Nahed A Hussien, Osama Al-Amer, Suliman Alomar* and Lamjed Mansour*


DOI: 10.2174/1871520621666210623094526
View Abstract






Current Insight into the Therapeutic Potential of Phytocompounds and their Nanoparticle-based Systems for Effective Management of Lung Cancer


Mahak Fatima, Mohammad Kashif Iqubal, Ashif Iqubal, Harsimran Kaur, Sadaf Jamal Gilani, Md. Habibur Rahman, Amirhossein Ahmadi and Md. Rizwanullah*


DOI: 10.2174/1871520621666210708123750
View Abstract


Ethnobotanical Study of Medicinal Plants Used for Management of Cancer in Karonga District, Northern Malawi


Bonface Mwamatope, David Tembo*, Ibrahim Chikowe, Cecilia Maliwichi-Nyirenda, Elizabeth Kampira and Friday Foster Masumbu


DOI: 10.2174/1871520621666210708122037
View Abstract




Published Contents

Editor's Choice



Synthesis of 1H-1,2,3-Triazole-Linked Quinoline-Isatin Molecular Hybrids as Anti-Breast Cancer and Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Agents

, 2021; 21(10): 1228 - 1239

Paul Awolade, Nosipho Cele, Oluwakemi Ebenezer, Nagaraju Kerru, Lalitha Gummidi, Liang Gu, Gabriella Palma, Mandeep Kaur and Parvesh Singh*


DOI: 10.2174/1871520620666200929153138



On the Cytotoxicity of Chiral Ruthenium Complexes Containing Sulfur Amino Acids against Breast Tumor Cells (MDA-231 and MCF-7)

, 2021; 21(9): 1172 - 1182

Celisnolia M. Leite*, João Honorato de Araujo-Neto, Rodrigo S. Corrêa, Legna Colina-Vegas, Diego Martínez-Otero, Paulo R. Martins, Cristiane G. Silva and Alzir A. Batista*


DOI: 10.2174/1871520620666200824114816



Synthesis and Evaluation of Cytotoxic Activity of Certain Benzo[h]chromene Derivatives

, 2021; 21(8): 963 - 986

Samir M. Awad, Mosaad S. Mohamed, Marwa Abd El-Fattah Khodair and Rania H. Abd El-Hameed*


DOI: 10.2174/1871520620666200925103742




Novel Dihydropyrimidinone-Derived Selenoesters as Potential Cytotoxic Agents to Human Hepatocellular Carcinoma: Molecular Docking and DNA Fragmentation

, 2021; 21(6): 703 - 715

Jean C. Benassi, Flavio A.R. Barbosa, Valdelúcia M.A.S. Grinevicius, Fabiana Ourique, Daniela Coelho, Karina B. Felipe, Antônio L. Braga, Danilo W. Filho and Rozangela C. Pedrosa*


DOI: 10.2174/1871520620666200728124640



Anticancer Active Heterocyclic Chalcones: Recent Developments

, 2021; 21(5): 558 - 566

Prasad Dandawate, Khursheed Ahmed, Subhash Padhye, Aamir Ahmad* and Bernhard Biersack*


DOI: 10.2174/1871520620666200705215722



Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid

, 2021; 21(4): 462 - 467

Agnieszka Siebert, Milena Deptuła, Mirosława Cichorek, Anna Ronowska, Grzegorz Cholewiński* and Janusz Rachon


DOI: 10.2174/1871520620666200516151456



Benzimidazole Derivative Ameliorates Opioid-Mediated Tolerance during Anticancer- Induced Neuropathic Pain in Mice

, 2021; 21(3): 365 - 371

Sana Akhtar, Muzaffar Abbas*, Komal Naeem, Muhammad Faheem, Humaira Nadeem and Amber Mehmood


DOI: 10.2174/1871520620999200818155031



Open Access Articles



The Killing of Human Neuroblastoma Cells by the Small Molecule JQ1 Occurs in a p53-Dependent Manner

, 2020; 20(13): 1613 - 1625

Joseph Mazar*, Caleb Gordon, Varun Naga and Tamarah J. Westmoreland




Cytotoxic Sesquiterpenes from Sonchus oleraceus

, 2020; 20(6): 709 - 714

Hongying Zhang, Yiding Wang, Shaojiu Wang, Qian Wang, Tianjing Wang, Jie Zhu* and Bing Liu




Proteomic Level Changes on Treatment in MCF-7/DDP Breast Cancer Drug- Resistant Cells

, 2020; 20(6): 687 - 699

Gongshen Jin*, Kangwei Wang, Yonghong Liu, Xianhu Liu, Xiaojing Zhang and Hao Zhang




Deglucohellebrin: A Potent Agent for Glioblastoma Treatment

, 2020; 20(1): 103 - 110

Evrysthenis Vartholomatos, George A. Alexiou*, Georgios S. Markopoulos, Diamanto Lazari, Olga Tsiftsoglou, Ieremias Chousidis, Ioannis Leonardos and Athanasios P. Kyritsis





Triphenylethylene-Coumarin Hybrid TCH-5c Suppresses Tumorigenic Progression in Breast Cancer Mainly Through the Inhibition of Angiogenesis

, 2019; 19(10): 1253 - 1261

Naipeng Cui, Dan-Dan Lin, Yang Shen, Jian-Guo Shi, Bing Wang, Ming-Zhi Zhao, Lishuang Zheng, Hua Chen* and Jian-Hong Shi*





New Strategies for Therapeutic Cancer Vaccines

, 2019; 19(2): 213 - 221

Hanjiao Qin, Jiyao Sheng, Dan Zhang, Xuewen Zhang, Linlin Liu*, Bingjin Li*, Guangquan Li* and Zhuo Zhang




Trichinella spiralis and Tumors: Cause, Coincidence or Treatment?

, 2018; 18(8): 1091 - 1099

Chengshui Liao*, Xiangchao Cheng, Mingyuan Liu*, Xuelin Wang and Pascal Boireau




Astragalin Attenuates UVB Radiation-induced Actinic Keratosis Formation

, 2018; 18(7): 1001 - 1008

Na Li, Kun Zhang, Xin Mu, Qiong Tian, Wenli Liu, Tianyuan Gao, Xiaona Ma* and Jian Zhang*





Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals

, 2016; 16(11): 1385 - 1402

Alessandra Bosutti, Fabrizio Zanconati, Gabriele Grassi, Barbara Dapas, Sabina Passamonti and Bruna Scaggiante




Blood-Brain Barrier and Breast Cancer Resistance Protein: A Limit to the Therapy of CNS Tumors and Neurodegenerative Diseases

, 2016; 16(7): 810 - 815

Anna Lisa Iorio, Martina da Ros, Ornella Fantappiè, Maurizio Lucchesi, Ludovica Facchini, Alessia Stival, Sabrina Becciani, Milena Guidi, Claudio Favre, Maurizio de Martino, Lorenzo Genitori and Iacopo Sardi





Most Cited Articles



Review Article

Crocetin and crocin from saffron in cancer chemotherapy and chemoprevention

, 2019; 19(1): 38-47.

Alessandro Colapietro, Andrea Mancini, Anna Maria D'Alessandro and Claudio Festuccia*


DOI: 10.2174/1871520619666181231112453


Research Article

Synthesis and biological evaluation of novel heterocyclic imines linked coumarin- thiazole hybrids as anticancer agents

, 2019; 19(4): 557-566.

Nerella S. Goud, Mahammad S. Ghouse, Jatoth Vishnu, Jakkula Pranay, Ravi Alvala, Venu Talla, Insaf A. Qureshi and Mallika Alvala*


DOI: 10.2174/1871520619666190207140120



Review Article

Phytochemicals in anticancer drug development

, 2019; 19(2): 172-183.

Rohit Dutt, Vandana Garg, Naveen Khatri and Anil K. Madan*


DOI: 10.2174/1871520618666181106115802



Research Article

Novel inhibitors of DNA repair enzyme TDP1 combining monoterpenoid and adamantane fragments

, 2019; 19(4): 463-472.

Evgenii S. Mozhaitsev, Alexandra L. Zakharenko, Evgeniy V. Suslov*, Dina V. Korchagina, Olga D. Zakharova, Inna A. Vasil'eva, Arina A. Chepanova, Ellena Black, Jinal Patel, Raina Chand, Jóhannes Reynisson, Ivanhoe K.H. Leung, Konstantin P. Volcho, Nariman F. Salakhutdinov and Olga I. Lavrik


DOI: 10.2174/1871520619666181207094243


Review Article

Garlic and its active compounds: A potential candidate in the prevention of cancer by modulating various cell signalling pathways

, 2019; 19(11): 1314-1324.

Saleh A. Almatroodi, Mohammed A. Alsahli, Ahmad Almatroudi and Arshad H. Rahmani*


DOI: 10.2174/1871520619666190409100955



Research Article

Let-7a could serve as a biomarker for chemo-responsiveness to docetaxel in gastric cancer

, 2019; 19(3): 304-309.

Najibeh Shekari, Faezeh Asghari, Navideh Haghnavaz, Dariush Shanehbandi, Vahid Khaze, Behzad Baradaran and Tohid Kazemi*


DOI: 10.2174/1871520619666181213110258




Research Article

Hydroxytyrosol and oleuropein inhibit migration and invasion of MDA-MB-231 triple-negative breast cancer cell via induction of autophagy

, 2019; 19(16): 1983-1990.

Hui-Yuan Lu*, Jian-Sheng Zhu, Zhan Zhang, Wei-Jian Shen, Shan Jiang, Yun-Feng Long, Bin Wu, Tao Ding, Fei Huan and Shou-Lin Wang


DOI: 10.2174/1871520619666190722101207


Research Article

[10]-gingerol affects multiple metastatic processes and induces apoptosis in MDA-MB-231 breast tumor cells

, 2019; 19(5): 645-654.

Angelina M. Fuzer, Ana C.B.M. Martin, Amanda B. Becceneri, James A. da Silva, Paulo C. Vieira and Marcia R. Cominetti*


DOI: 10.2174/1871520618666181029125607



Most Accessed Articles


Chalcone Scaffolds as Anticancer Drugs: A Review on Molecular Insight in Action of Mechanisms and Anticancer Properties

, 2021; 21(13): 1650-1670.

Shefali Shukla, Anantpreet K. Sood, Kartika Goyal, Ambika Singh, Vaidehi Sharma, Neha Guliya, Shikha Gulati and Sanjay Kumar*


DOI: 10.2174/1871520620999201124212840


The Potential Clinical Value of Curcumin and its Derivatives in Colorectal Cancer

, 2021; 21(13): 1626-1637.

Zhaoying Yao, Thi Ha Le, Qianming Du, Huiwen Mu, Chao Liu* and Yubing Zhu*


DOI: 10.2174/1871520620999201113095821


Effect of Dasatinib on Genes Related to Mitotic Catastrophe Pathway in Chronic Myeloid Leukemia Cells

, 2021; 21(13): 1724-1731.

Sezgi Kipcak, Buket Ozel, Cigir Biray Avci*, Leila S. Takanlou, Maryam S. Takanlou, Cumhur Gunduz and Nur Selvi Gunel


DOI: 10.2174/1871520620666201106085929



Synthesis, Molecular Docking and Biological Activity Evaluation of Alkoxy Substituted Chalcone Derivatives: Potential Apoptosis Inducing Agent on MCF-7 Cells

, 2021; 21(13): 1738-1750.

Wan M. Khairul*, Fatimah Hashim*, Mas Mohammed, Nurul Shazwani Mohd Norhadi Shah, Syed Ahmad Tajudin Tuan Johari, Rafizah Rahamathullah, Adibah Izzati Daud and Nyuk Ling Ma


DOI: 10.2174/1871520620999201110190709








Curbing the Deregulation of Glycosylation in Tongue Carcinoma Cells with Natural Compounds

, 2021; 21(13): 1717-1723.

Kruti A. Mehta, Kinjal A. Patel, Ajai B. Kunnumakkara and Prabhudas S. Patel*


DOI: 10.2174/1871520620999201124213259






Editor-in-Chief

graphic
Simone Carradori
Department of Pharmacy
“G. d’Annunzio” University of Chieti-Pescara
Chieti
(Italy)
Biography
View Full Editorial Board

COPE Compliant

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Journal History

Current Medicinal Chemistry - Anti-Cancer Agents was launched in 2001 and later renamed in 2006 as Anti-Cancer Agents in Medicinal Chemistry.

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