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Current Topics in Medicinal Chemistry

Volume 21, 32 Issues, 2021
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Articles Ahead of Print


Contrasting Roles of the Galectin-3 in the Schizophrenia Onset, Clinical Presentation, and Somatic Comorbidity


Milica M. Borovcanin*, Gordana D. Radosavljevic, Jelena Pantic, Jelena Milovanovic, Natasa R. Mijailovic, Aleksandar N. Arsenijevic and Nebojsa N. Arsenijevic


DOI: 10.2174/1568026621666210611162420
View Abstract View on PubMed





The Role of Peroxisome Proliferator-Activated Receptor in Addiction: A Novel Drug Target


Carla Quiroga, Juan José Barberena, Jocelyne Alcaraz-Silva , Sérgio Machado, Claudio Imperatori , Ali Yadollahpour , Henning Budde, Tetsuya Yamamoto, Diogo Telles-Correia and Eric Murillo-Rodríguez *


DOI: 10.2174/1568026621666210521165532
View Abstract View on PubMed


Application of In silico Methods in the Design of Drugs for Neurodegenerative Diseases


Mohamad Haider, Anjali Chauhan, Sana Tariq, Dharam Pal Pathak, Nadeem Siddiqui, Soni Ali, Faheem Hyder Pottoo and Ruhi Ali*


DOI: 10.2174/1568026621666210521164545
View Abstract View on PubMed



Cellular Bioenergetic and Metabolic Changes in Patients with Autism Spectrum Disorder


Maria Gevezova, Danail Minchev, Iliana Pacheva, Yordan Sbirkov, Ralitsa Yordanova, Elena Timova, Vasil Kotetarov, Ivan Ivanov and Victoria Sarafian*


DOI: 10.2174/1568026621666210521142131
View Abstract



Abstracts Ahead of Print

Molecular Mechanism of Inhibition of Polysialyltransferase Domain (PSTD) by Heparin


Si-Min Liao, Xue-Hui Liu, Li-Xing Peng, Bo Lu, Ri-Bo Huang and Guo-Ping Zhou*


DOI: 10.2174/1568026621666210713165251
View Abstract





Flavonoid derivatives targeting BCR-ABL kinase: Semisynthesis, Molecular dynamic simulations and Enzymatic inhibition.


Rayssa Ribeiro, Mariana Alves Eloy, Carla Santana Francisco, Clara Lirian Javarini, Gabriela Miranda Ayusso, Victor Da Rocha Fonseca, Wanderson Romão, Luis Octavio Regasini, Sheila Cruz Araujo, Michell Oliveira Almeida, Kathia Maria Honorio, Heberth de Paula, Valdemar Lacerda Jr.* and Pedro Alves Bezerra Morais*


DOI: 10.2174/1568026621666210705170047
View Abstract



Nanotechnology, a tool for diagnostics and treatment of cancer


Abdul Nasir, Amir Khan, Jiayi Li, Muhammad Naeem, Atif Ali Khan Khalil, Khalid Khan and Muhammad Qasim*


DOI: 10.2174/1568026621666210701144124
View Abstract


Relevance of Aromatase Inhibitors in Breast Cancer Treatment


Ankita Sood, Damanpreet Kaur Lang, Rajwinder Kaur*, Balraj Saini and Sandeep Arora


DOI: 10.2174/1568026621666210701143445
View Abstract



Eugenol as a potential drug candidate: A review


Mohamad Taleuzzaman, Pooja Jain, Rishabh Verma, Zeenat Iqbal and Mohd. Aamir Mirza*


DOI: 10.2174/1568026621666210701141433
View Abstract


Published Contents

Editor's Choice

Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*


DOI: 10.2174/1568026618666180821145215




A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*


DOI: 10.2174/1568026618666180516123229




Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610






Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao


DOI: 10.2174/1568026618666180410151518



Aurora Kinase Inhibitors in Head and Neck Cancer

, 2018; 18(3): 199 - 213

Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang* and Yasusei Kudo*


DOI: 10.2174/1568026618666180112163741



Open Access Articles

An Overview of Ovarian Cancer: Molecular Processes Involved and Development of Target-based Chemotherapeutics

, 2021; 21(4): 329 - 346

Basheerulla Shaik, Tabassum Zafar, Krishnan Balasubramanian and Satya P. Gupta*





Beyond DNA-targeting in Cancer Chemotherapy. Emerging Frontiers - A Review

, 2021; 21(1): 28 - 47

Simon N. Mbugua, Lydia W. Njenga, Ruth A. Odhiambo, Shem O. Wandiga and Martin O. Onani*




Peptide Receptor Radionuclide Therapy: Looking Back, Looking Forward

, 2020; 20(32): 2959 - 2969

Danny Feijtel, Marion de Jong and Julie Nonnekens*




Learning the Edit Costs of Graph Edit Distance Applied to Ligand-Based Virtual Screening

, 2020; 20(18): 1582 - 1592

Carlos Garcia-Hernandez, Alberto Fernández* and Francesc Serratosa




Telomere-related Markers for Cancer

, 2020; 20(6): 410 - 432

Xiaotian Yuan*, Mingkai Dai and Dawei Xu*






Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621 - 1649

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*




Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

, 2019; 19(16): 1399 - 1417

Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May* and Jianing Li*




Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity

, 2019; 19(11): 957 - 969

Ana Yisel Caballero-Alfonso, Maykel Cruz-Monteagudo, Eduardo Tejera, Emilio Benfenati, Fernanda Borges, M. Natália D.S. Cordeiro, Vinicio Armijos-Jaramillo and Yunierkis Perez-Castillo*





Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*




Mechanical Properties of Composite Hydrogels for Tissue Engineering

, 2018; 18(14): 1214 - 1223

Ramon Rial, J.F. Armando Soltero, Pedro V. Verdes, Zhen Liu and Juan M. Ruso*






Most Cited Articles


Review Article

Molecular hybridization as a tool for designing multitarget drug candidates for complex diseases

, 2019; 19(19): 1694-1711.

Viktoriya Ivasiv, Claudia Albertini, Ana E. Gonçalves, Michele Rossi and Maria L. Bolognesi*


DOI: 10.2174/1568026619666190619115735




Review Article

Biological activities of artemisinin derivatives beyond malaria

, 2019; 19(3): 205-222.

Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao* and Jingshan Shen


DOI: 10.2174/1568026619666190122144217


Review Article

Mycobacterial tuberculosis Enzyme Targets and their Inhibitors

, 2019; 19(5): 337-355.

Anil Kumar Saxena* and Anamika Singh


DOI: 10.2174/1568026619666190219105722


Review Article

Biological signatures of alzheimer’s disease

, 2020; 20(9): 770-781.

Poornima Sharma, Anjali Sharma, Faizana Fayaz, Sharad Wakode* and Faheem H. Pottoo


DOI: 10.2174/1568026620666200228095553




Review Article

Discovery and development of anti-HIV therapeutic agents: Progress towards improved HIV medication

, 2019; 19(18): 1621-1649.

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*


DOI: 10.2174/1568026619666190712204603


Review Article

Emerging complexity and the need for advanced drug delivery in targeting Candida species

, 2019; 19(28): 2593-2609.

Ridhima Wadhwa, Parijat Pandey, Gaurav Gupta, Taru Aggarwal, Nitesh Kumar, Meenu Mehta, Saurabh Satija, Monica Gulati, Jyotsna Madan, Harish Dureja, Sri R. Balusamy, Haribalan Perumalsamy, Pawan K. Maurya, Trudi Collet, Murtaza M. Tambuwala, Philip M. Hansbro, Dinesh Kumar Chellappan* and Kamal Dua*


DOI: 10.2174/1568026619666191026105308


Review Article

Virtual screening techniques in drug discovery: Review and recent applications

, 2019; 19(19): 1751-1767.

Sheisi F.L. da Silva Rocha, Carolina G. Olanda, Harold H. Fokoue and Carlos M.R. Sant'Anna*


DOI: 10.2174/1568026619666190816101948



Review Article

STAT3: A potential drug target for tumor and inflammation

, 2019; 19(15): 1305-1317.

Yang Sheng Hu, Xu Han and Xin Hua Liu*


DOI: 10.2174/1568026619666190620145052




Most Accessed Articles



Akt Pathway Inhibitors

, 2020; 20(10): 883-900.

Nne E. Uko, Osman F. Güner, Diane F. Matesic and J. Phillip Bowen*


DOI: 10.2174/1568026620666200224101808



Role of Phytomolecules in the Treatment of Obesity: Targets, Mechanisms and Limitations

, 2021; 21(10): 863-877.

Shampa Ghosh, Srividya Manchala , Manchala Raghunath, Gaurav Sharma , Abhishek K. Singh* and Jitendra K. Sinha *


DOI: 10.2174/1568026621666210305101804


The Bioactive Potential of Culturable Fungal Endophytes Isolated From the Leaf of Catharanthus roseus (L.) G. Don

, 2021; 21(10): 895-907.

Sucheta Singh*, Surjeet Verma, Dharmendra K. Yadav, Anant Kumar, Rekha Tyagi, Priyanka Gupta, Dnyaneshwar U. Bawankule, Mahendra P. Darokar, Santosh K. Srivastava and Alok Kalra


DOI: 10.2174/1568026621666210426123437



Potential Therapeutic Relevance of CRISPR/Cas9 Guided Epigenetic Regulations for Neuropsychiatric Disorders

, 2021; 21(10): 878-894.

Desh D. Singh*, Ravi Verma, Piyush Parimoo, Ashish Sahu, Vikram Kumar, Era Upadhyay and Dharmendra K. Yadav


DOI: 10.2174/1568026621666210317154502




In-silico Studies and Wet-Lab Validation of Camptothecin Derivatives for Anti-Cancer Activity Against Liver (HepG2) and Lung (A549) Cancer Cell Lines

, 2021; 21(10): 908-919.

Komal Kalani, Dharmendra K. Yadav, Sarfaraz Alam, Feroz Khan, Mahendra P. Kashyap, Santosh K. Srivastava* and Aditya B. Pant


DOI: 10.2174/1568026621666210426124719


Organic Antifungal Drugs and Targets of Their Action

, 2021; 21(8): 705-736.

Alexander Yu Maksimov*, Svetlana Yu Balandina, Pavel A. Topanov, Irina V. Mashevskaya and Sandeep Chaudhary


DOI: 10.2174/1568026621666210108122622



Therapeutic Potential of microRNA Against Th2-associated Immune Disorders

, 2021; 21(8): 753-766.

Sunil Kumar, Muhammad Umer Ashraf, Anil Kumar and Yong-Soo Bae*


DOI: 10.2174/1568026621666210303150235


Azithromycin Use in COVID-19 Patients: Implications on the Antimicrobial Resistance

, 2021; 21(8): 677-683.

Gabriela Seabra, Roberta Ferreira Ventura Mendes, Luiz Felipe Vieira dos Santos Amorim, Ingrid Vianez Peregrino, Marta Helena Branquinha, André Luis Souza dos Santos* and Ana Paula Ferreira Nunes*


DOI: 10.2174/156802662108210319145317




Editor-in-Chief

graphic
Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX
(USA)
Biography
View Full Editorial Board

COPE Compliant

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Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who served as the editor-in-chief from 2001 to 2020. Currently, Dr. Jia Zhou is the Editor-in-Chief of the journal.

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